Lithium Diisopropylamide (lda) as an Efficient Reducing Agent for Thioketones - Mechanistic Consideration

Treatment of thiocarbonyl compounds with excess LDA leads to the corresponding thiols or sulfides depending on the work-up procedure. The mechanistic scenario for this unusual reduction pathway is discussed. DOI: https://doi.org/10.1080/10426507.2015.1012201 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-112069 Accepted Version Originally published at: Jasinski, Marcin; Mloston, Grzegorz; Gebert, Andreas; Heimgartner, Heinz (2015). Lithium diisopropylamide (lda) as an efficient reducing agent for thioketones mechanistic consideration. Phosphorus, Sulfur, and Silicon and the Related Elements, 190:1281-1284. DOI: https://doi.org/10.1080/10426507.2015.1012201 LITHIUM DIISOPROPYLAMIDE (LDA) AS AN EFFICIENT REDUCING AGENT FOR THIOKETONES MECHANISTIC CONSIDERATION Marcin Jasiński, Grzegorz Mlostoń,* Andreas Gebert, and Heinz Heimgartner a Faculty of Chemistry, University of Łódź, Tamka 12, PL 91-403 Łódź, Poland b Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH8057 Zurich, Switzerland